A powerful combination of vitamins D3 and K2 for strong and healthy bones

From a young age, we are taught that for strong and healthy bones it is important to consume enough milk and dairy products, to be exposed to the sun and to eat fatty fish, crabs and seafood, some types of mushrooms and egg yolks, in order to synthesize a sufficient amount of vitamin D. But do you know that the health of your bones depends not only on calcium and vitamin D?

Iako je vitamin D₃ (kolekalciferol) poznat kao ključan čimbenik u apsorpciji kalcija, znanstvena istraživanja ukazuju na to da je za njegovu potpunu učinkovitost potreban vitamin K₂. These two vitamins work synergistically, and this connection can be crucial in preventing osteoporosis and reducing the risk of fractures, especially in old age.

How do vitamins D work?₃ i K₂?

Vitamin D₃ it helps the body to absorb calcium from food through the intestines and thereby increases the level of calcium in the blood. However, calcium itself, free and without interactions with proteins, can end up where it is not wanted, for example in blood vessels, which can contribute to the formation of calcifications and increase the risk of cardiovascular diseases.

That's where vitamin K comes in₂ (menakinon), koji aktivira posebne proteine ovisne o vitaminu K, poput osteokalcina i MGP-a (matrix Gla proteina), koji they direct calcium into bones and teeth, and prevent its deposition in soft tissues and blood vessels.

A review of numerous studies confirms that the combination of vitamins D and K is more effective than either vitamin alone. Animal and human studies show:

• better mineralizaciju kostiju – suplementacija D₃ i K₂ poboljšava gustoću kostiju i smanjuje rizik od prijeloma, osobito kod postmenopauzalnih žena,
• activation osteokalcina – vitamin D potiče njegovu proizvodnju, dok K₂ osigurava njegovu aktivnost (karboksilaciju) te
• prevention vaskularne kalcifikacije – kombinacija ovih vitamina pomaže u zaštiti arterija od nakupljanja kalcija, što može smanjiti rizik od srčanog i moždanog udara.

Vitamin K exists in two forms: K₁ (uglavnom u zelenom lisnatom povrću) i K₂ (u fermentiranim proizvodima poput nekih sireva). Za zdravlje kostiju i srca posebno se ističe vitamin K₂, especially in the form of MK-7, because it has greater bioavailability and a longer duration of action in the body. Although recommended doses for vitamin D3 are known (usually 800 to 2000 IU per day, depending on age and condition), the recommended daily dose of vitamin K₂ iznosi 75 µg, iako se u studijama najčešće koristi doza od 90 do 180 µg dnevno za MK-7.

Vitamin D combination₃ i K₂ može imati dalekosežne učinke na zdravlje kostiju, ali i na kardiovaskularni sustav. It is important to emphasize that high doses of vitamin D without sufficient levels of vitamin K can even be harmful - due to the risk of excessive accumulation of calcium where it should not be.

Meet smart support za vaše kosti, hrskavicu i mišiće – u samo jednoj kapsuli dnevno

Almagea® MOTION SUPPORT+ is a new generation nutritional supplement formulated for those who want to maintain the vitality of movement in all phases of life. Contains a unique combination of clinically tested ingredients:

• UC-II®, which is a patented form of undenatured type II collagen. As little as 40 mg of UC-II® per day can have a comparable effect to traditional high doses of glucosamine and chondroitin.
• Vitamin K₂ and D₃ koji doprinose održavanju normalnih kostiju.
• Vitamin D₃ which contributes to the maintenance of normal muscle function.
• Vitamin C, which contributes to the normal formation of collagen for the normal function of cartilage and bones.

Kolagen tipa II ključni je strukturni protein hrskavice koji omogućuje elastičnost, čvrstoću i glatko kretanje zglobova. S godinama i opterećenjem njegova se količina smanjuje što može dovesti do cartilage wear and joint pain. Dietary supplements with undenatured type II collagen, such as UC-II®, help maintain cartilage health and improve mobility. The action of undenatured collagen type II (UC-II®) is supported by clinical studies, and in combination with vitamins K₂ and D₃, a synergistic effect is created that supports: joint mobility and flexibility, preservation of bone density, and cartilage and muscle health.

Almagea® MOTION SUPPORT+ namijenjen je:

• people with limited mobility and joint pain,
• elderly people to preserve bone mass and joint function,
• athletes and recreationists who want to protect cartilage and muscles in the long term and
• to everyone who wants to preventively preserve the health of the locomotor system.

Zbog svoje jedinstvene formule Almagea® MOTION SUPPORT+ pruža comprehensive support for the health of joints, bones and muscles. Svaki sastojak djeluje ciljano i sinergijski: collagen restores the cartilage structure, vitamin C promotes its natural regeneration, while the combination of D₃ i K₂ ensures proper absorption and incorporation of calcium into bones. Upravo zato, Motion Support+ je pametan izbor za sve koji žele očuvati pokretljivost, smanjiti nelagodu u zglobovima i dugoročno podržati zdravlje lokomotornog sustava.

Literature:

• van Ballegooijen, A. J., Pilz, S., Tomaschitz, A., Grübler, M. R., & Verheyen, N. (2017). The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review. International journal of endocrinology, 2017, 7454376.
• Iwamoto, J., Takeda, T., & Ichimura, S. (2000). Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis. Journal of orthopedic science: official journal of the Japanese Orthopedic Association, 5(6), 546–551.
• Skalny, A. V., Aschner, M., Tsatsakis, A., Rocha, J. B. T., Santamaria, A., Spandidos, D. A., Martins, A. C., Lu, R., Korobeinikova, T. V., Chen, W., Chang, J. S., Chao, J. C. J., Li, C., & Tinkov, A. A. (2024). Role of vitamins beyond vitamin D₃ in bone health and osteoporosis (Review). International journal of molecular medicine, 53(1), 9.